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  • SpaceX Starship reaches orbit 🚀, DNA foundational models 🧬, curse of senior devs 👨‍💻

    From TLDR@VERT to tldr@synchro.net on Fri Mar 15 10:39:30 2024
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    SpaceX's Starship rocket flew halfway around the world yesterday=C2=A0=20
    =

    Sign Up [1] | Advertise [2]|View Online [3]=20

    =09=09TLDR=20

    =09=
    =09TOGETHER WITH
    [https://arstechnica.com/space/2024/03/after-its-third-t= est-flight-spacexs-starship-could-soon-carry-satellites/]
    [4]

    TLDR 2=
    024-03-15

    WANT TO=C2=A0ADVERTISE=C2=A0IN=C2=A0TLDR? (SPONSOR) [5]=20
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    BIG TECH &=
    STARTUPS

    SPACEX CELEBRATES MAJOR PROGRESS ON THE THIRD FLIGHT OF STA=
    RSHIP (7
    MINUTE READ) [6]=20

    SpaceX's Starship rocket flew halfway ar=
    ound the world yesterday,
    accomplishing a key demonstration of its abilit=
    y to carry heavy
    payloads into low-Earth orbit. The successful launch bui=
    lds on two
    previous flights last year. Thursday's flight tested Starship'=
    s
    payload bay door and performed a precursor test of an in-orbit
    refuel=
    ing system. Photos from the launch are available in the article.


    W=
    HO COULD BUY TIKTOK? THESE ARE THE PEOPLE WHO COULD ACQUIRE THE APP
    (7 MI=
    NUTE READ) [7]=20

    ByteDance may have to sell TikTok in the US if a prop=
    osed bill passes
    the Senate. Some high-profile investors, including forme=
    r Treasury
    Secretary Steven Mnuchin, online video platform Rumble, and fo=
    rmer
    Activision Blizzard CEO Bobby Kotick, have expressed interest in
    a=
    cquiring the app. This article presents a list of known potential
    buyers =
    along with a primer on companies that have previously tried to
    purchase T=
    ikTok.=20

    =F0=9F=9A=80=20

    SCIENCE & FUTURISTIC TECHNOLOGY

    EVO: =
    DNA FOUNDATION MODELING FROM MOLECULAR TO GENOME SCALE (9 MINUTE
    READ) [8=
    ]=20

    Evo is a long-context biological foundation model capable of both=

    prediction tasks and generative design, from molecular to whole genome=

    scale. The model generalizes across the fundamental languages of
    biolo=
    gy, DNA, RNA, and proteins to generate DNA sequences using a
    context leng=
    th of 131k tokens. It is based on StripedHyena, a deep
    signal processing =
    architecture designed to improve efficiency and
    quality over prevailing T=
    ransformer architecture. A playground is
    available where users can genera=
    te DNA in their browsers using Evo.=20

    GENETICALLY MODIFIED COW MAKES M=
    ILK WITH HUMAN INSULIN (5 MINUTE
    READ) [9]=20

    Researchers have engine=
    ered a cow capable of producing milk that
    contains human insulin. This co=
    uld result in an alternative for
    insulin production. The process involves=
    inserting human DNA coding
    for insulin into cow embryos. It could dramat=
    ically simplify the
    process and cost of producing the drug. A single cow =
    can produce
    enough milk every day to supply thousands of type 1 diabetes =
    patients
    with their daily insulin for an entire month. Scaling up product=
    ion,
    ensuring the health and welfare of the transgenic cows, and navigati=
    ng
    regulatory approvals are still huge challenges that lie ahead before=

    the process can replace conventional methods of insulin production.=20
    =

    =F0=9F=92=BB=20

    PROGRAMMING, DESIGN & DATA SCIENCE

    =F0=9F=94=
    =92 ENHANCE YOUR APPSEC: 5 STRATEGIC CHECKPOINTS! =F0=9F=94=8D (SPONSOR)
    =
    [10]=20

    =F0=9F=9A=80 Prepare for ASPM implementation with SNYK'S CHEAT =
    SHEET 5
    STRATEGIC SECURITY CHECKPOINTS! [10]Analyze app inventory, compli=
    ance,
    risks, vulnerabilities, and controls for a robust security program.=

    Don't leave your app vulnerable! =F0=9F=92=AA Download the Cheat Sheet [= 10]=20

    FALSEHOODS PROGRAMMERS BELIEVE ABOUT TIME ZONES (10 MINUTE READ)=
    [11]


    Building a time zone conversion layer on top of a datetime l=
    ibrary
    sounds like an easy task, but it isn't. This article lists 21
    mi=
    sconceptions about time zones the author had before attempting to
    write a=
    time zone conversion app as well as extra misconceptions from
    readers. T=
    hese misconceptions include thinking that there are more
    countries in the=
    world than time zones, that every time zone has
    exactly one agreed-upon =
    name, or that time zones are always offset
    from UTC by an integer number =
    of hours.=20

    HTTP/2 AND HTTP/3 EXPLAINED (25 MINUTE READ) [12]=20

    T=
    he first HTTP draft had only one method, GET - there were no headers
    or s=
    tatus codes, and the only data format available was HTML. The
    protocol ha=
    s evolved significantly since then. HTTP/3 is designed for
    unstable conne=
    ctions, resulting in performance tradeoffs. HTTP/2
    offers better performa=
    nce on reliable and stable connections than
    HTTP/3. Servers can accept bo=
    th HTTP/2 and HTTP/3 connections so
    clients can make the decision of whic=
    h version to use.=20

    =F0=9F=8E=81=20

    MISCELLANEOUS

    THE TOP 100 =
    GEN AI CONSUMER APPS (11 MINUTE READ) [13]=20

    AI-native products and co=
    mpanies are growing faster and engaging
    users more deeply than ever befor=
    e. Over the coming decade, AI will
    likely underpin category-defining comp=
    anies. This article examines
    data on the most popular generative AI produ=
    cts to uncover patterns on
    how consumers are using the technology. It loo=
    ks at the rate of
    progress in the industry, emerging categories, hot nich=
    es, the mobile
    vs web split, and AI as a global pursuit.=20

    THE CURSE=
    OF THE SENIOR SOFTWARE ENGINEER (11 MINUTE READ) [14]=20

    Titles help n=
    ormalize pay ranges and allow for progression and
    evaluation. People who =
    are not job hoppers or get stuck in the same
    company and title due to laz=
    iness, comfort, or other reasons are
    unfortunately prone to 'The Curse of=
    the Senior Software Engineer'.
    This is when an engineer who has been sen=
    ior for too long finds
    themselves between two worlds upon their next job =
    search: they are too
    senior to be hired as a senior or they have too litt=
    le leadership
    experience to be hired in a leadership position. Avoiding t=
    he curse
    involves either playing by corporate rules or exiting the game b=
    y
    switching to self-employment.=20

    =E2=9A=A1=20

    QUICK LINKS

    S=
    NAPCHAT WILL ALLOW USERS TO SAVE DMS (2 MINUTE READ) [15]=20

    Snapchat i=
    s experimenting with an 'Infinite Retention Mode' that will
    allow users t=
    o save their direct messages.=20

    AFTER AWS AND GOOGLE, MICROSOFT SAYS I=
    T=E2=80=99S REMOVING AZURE
    =E2=80=98EGRESS=E2=80=99 DATA TRANSFER FEES =
    =E2=80=94 BUT WITH CAVEATS (3 MINUTE READ)
    [16]=20

    Microsoft will all=
    ow business customers to transfer data out of its
    Azure cloud infrastruct=
    ure with no egress fees to align with
    stipulations set out in the Europea=
    n Data Act, but only for customers
    looking to completely end their associ=
    ation with Azure.=20

    THE MOST IMPORTANT SKILL IN STARTUP ENGINEERING LE=
    ADERSHIP (4 MINUTE
    READ) [17]=20

    The singular skill that ultimately d=
    ecides the success of a leader
    and their team is pacing - leaders must be=
    in tune with their and
    their team's abilities and stamina.=20

    THE FU=
    TURE OF FARCASTER WITH DAN ROMERO (22 MINUTE READ) [18]=20

    Dan Romero, =
    the founder of Farcaster, a disruptive social network,
    talks in this inte=
    rview about competing directly against Elon Musk,
    nerd sniping, predictio=
    n markets, and new business models.=20

    TO THE SPACE STATION (WEBSITE) [=
    19]=20

    This page explains SpaceX's Dragon's docking and reentry procedu=
    res.=20

    DIGITAL FORGERIES ARE HARD (6 MINUTE READ) [20]=20

    Expert w=
    itnesses on both sides of the case over whether Craig Wright
    is Satoshi N=
    akamoto agree that much of the digital evidence provided
    by Wright is unr=
    eliable in one way or another.=20

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    AI, Information Security,
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    Thanks for reading,=20
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    [4] SpaceX%20celebrates%20major%20progress%20on%20th= e%20third%20flight%20of%20Starship%20(7%20minute%20read)
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    [13] https://a16z.com/100-gen-ai-apps/?utm_source=3Dtldrne=
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    [15] https://www.axios.com/2024/03/14/= snapchat-messages-disappear-save-imessage-whatsapp?utm_source=3Dtldrnewslet= ter
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    --HD8p8Yrp
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    <div style=3D"display:none; font-size:0px; line-height:0px; max-height:0px;=
    max-width:0px; opacity:0; overflow:hidden; visibility:hidden; mso-hide:all= ;">SpaceX&#039;s Starship rocket flew halfway around the world yesterday&nb= sp;</div>


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    <table align=3D"center" bgcolor=3D"" border=3D"0" cellpadding=3D"0" cellspa= cing=3D"0" width=3D"100%"><tbody><tr><td class=3D"container" style=3D"paddi= ng-top: 0px; padding-bottom: 0px;">
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    <h3><strong>Big Tech &amp; Startups</strong></h3>
    </div>
    </div>
    </td></tr></tbody></table>

    <table style=3D"table-layout: fixed; width: 100%;" width=3D"100%"><tbody><t= r><td style=3D"padding:0;border-collapse:collapse;border-spacing:0;margin:0=
    ;" valign=3D"top">

    <table align=3D"center" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" wi= dth=3D"100%"><tbody><tr><td class=3D"container" style=3D"padding: 15px 15px=

    <div class=3D"text-block">
    <span>
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    <span>
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    </span>



    <span style=3D"font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, V= erdana, sans-serif;">
    SpaceX's Starship rocket flew halfway a= round the world yesterday, accomplishing a key demonstration of its ability=
    to carry heavy payloads into low-Earth orbit. The successful launch builds=
    on two previous flights last year. Thursday's flight tested Starship's pay= load bay door and performed a precursor test of an in-orbit refueling syste=
    m. Photos from the launch are available in the article.
    </span>
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    <table align=3D"center" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" wi= dth=3D"100%"><tbody><tr><td class=3D"container" style=3D"padding: 15px 15px=

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    <span>
    <a href=3D"https://tracking.tldrnewsletter.= com/CL0/https:%2F%2Fwww.nbcnews.com%2Ftech%2Fsocial-media%2Ftiktok-ban-sale= -buy-bill-law-download-app-senate-date-rcna143413%3Futm_source=3Dtldrnewsle= tter/1/0100018e41b209fb-cd11af79-9320-4d46-8e6c-11816e5f8ed0-000000/c8JCWKL= GZhzX0AiDYXlV2-X5jDgO-_4XwPSK9QZv0-E=3D344">
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    are the people who could acquire the app (7 minute read)</strong>
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    <span style=3D"font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, V= erdana, sans-serif;">
    ByteDance may have to sell TikTok in th=
    e US if a proposed bill passes the Senate. Some high-profile investors, inc= luding former Treasury Secretary Steven Mnuchin, online video platform Rumb= le, and former Activision Blizzard CEO Bobby Kotick, have expressed interes=
    t in acquiring the app. This article presents a list of known potential buy= ers along with a primer on companies that have previously tried to purchase=
    TikTok.
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    <table align=3D"center" bgcolor=3D"" border=3D"0" cellpadding=3D"0" cellspa= cing=3D"0" width=3D"100%"><tbody><tr><td class=3D"container" style=3D"paddi= ng-top: 0px; padding-bottom: 0px;">
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    <h3><strong>Science &amp; Futuristic Technology</strong></h3>
    </div>
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    </td></tr></tbody></table>

    <table style=3D"table-layout: fixed; width: 100%;" width=3D"100%"><tbody><t= r><td style=3D"padding:0;border-collapse:collapse;border-spacing:0;margin:0=
    ;" valign=3D"top">

    <table align=3D"center" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" wi= dth=3D"100%"><tbody><tr><td class=3D"container" style=3D"padding: 15px 15px=

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    g from molecular to genome scale (9 minute read)</strong>
    </span>



    <span style=3D"font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, V= erdana, sans-serif;">
    Evo is a long-context biological founda= tion model capable of both prediction tasks and generative design, from mol= ecular to whole genome scale. The model generalizes across the fundamental = languages of biology, DNA, RNA, and proteins to generate DNA sequences usin=
    g a context length of 131k tokens. It is based on StripedHyena, a deep sign=
    al processing architecture designed to improve efficiency and quality over = prevailing Transformer architecture. A playground is available where users = can generate DNA in their browsers using Evo.
    </span>
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    <table align=3D"center" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" wi= dth=3D"100%"><tbody><tr><td class=3D"container" style=3D"padding: 15px 15px=

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    <span>
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    <strong>Genetically modified cow ma= kes milk with human insulin (5 minute read)</strong>
    </span>



    <span style=3D"font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, V= erdana, sans-serif;">
    Researchers have engineered a cow capab=
    le of producing milk that contains human insulin. This could result in an a= lternative for insulin production. The process involves inserting human DNA=
    coding for insulin into cow embryos. It could dramatically simplify the pr= ocess and cost of producing the drug. A single cow can produce enough milk = every day to supply thousands of type 1 diabetes patients with their daily = insulin for an entire month. Scaling up production, ensuring the health and=
    welfare of the transgenic cows, and navigating regulatory approvals are st= ill huge challenges that lie ahead before the process can replace conventio= nal methods of insulin production.
    </span>
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    </td></tr></tbody></table>


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    <h3><strong>Programming, Design &amp; Data Science</strong></h3>
    </div>
    </div>
    </td></tr></tbody></table>

    <table style=3D"table-layout: fixed; width: 100%;" width=3D"100%"><tbody><t= r><td style=3D"padding:0;border-collapse:collapse;border-spacing:0;margin:0=
    ;" valign=3D"top">

    <table align=3D"center" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" wi= dth=3D"100%"><tbody><tr><td class=3D"container" style=3D"padding: 15px 15px=

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    <span>
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    <span>
    <strong>=F0=9F=94=92 Enhance Your A= ppSec: 5 Strategic Checkpoints! =F0=9F=94=8D (Sponsor)</strong>
    </span>



    <span style=3D"font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, V= erdana, sans-serif;">
    =F0=9F=9A=80 Prepare for ASPM implement= ation with <a href=3D"https://tracking.tldrnewsletter.com/CL0/https:%2F%2Fg= o.snyk.io%2Faspm-evaluating-you-appsec-landscape.html%3Futm_campaign=3Ddm_p= p-tldr_240315_con_240213_ad_aspm_evaluating_your_appsec_landscape%26utm_med= ium=3Dem-pa%26utm_source=3Dtldr%26utm_content=3Dcon_240213_ad_aspm_evaluati= ng_your_appsec_landscape/2/0100018e41b209fb-cd11af79-9320-4d46-8e6c-11816e5= f8ed0-000000/hiQAgIGI2Tw2XrPmiJdcs8rME4SIb2KwubW_f-SKLDM=3D344" rel=3D"noop= ener noreferrer nofollow" target=3D"_blank"><span><strong>Snyk's cheat shee=
    t 5 Strategic Security Checkpoints</strong>! </span></a>Analyze app invento= ry, compliance, risks, vulnerabilities, and controls for a robust security = program. Don't leave your app vulnerable! =F0=9F=92=AA <a href=3D"https://t= racking.tldrnewsletter.com/CL0/https:%2F%2Fgo.snyk.io%2Faspm-evaluating-you= -appsec-landscape.html%3Futm_campaign=3Ddm_pp-tldr_240315_con_240213_ad_asp= m_evaluating_your_appsec_landscape%26utm_medium=3Dem-pa%26utm_source=3Dtldr= %26utm_content=3Dcon_240213_ad_aspm_evaluating_your_appsec_landscape/3/0100= 018e41b209fb-cd11af79-9320-4d46-8e6c-11816e5f8ed0-000000/kx9n66uwLUvkdoUf8l= LpoAYAtPXPCsATGZb9-uUtZH0=3D344" rel=3D"noopener noreferrer nofollow" targe= t=3D"_blank"><span>Download the Cheat Sheet</span></a>
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    <table align=3D"center" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" wi= dth=3D"100%"><tbody><tr><td class=3D"container" style=3D"padding: 15px 15px=

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    <span>
    <a href=3D"https://tracking.tldrnewsletter.= com/CL0/https:%2F%2Fwww.zainrizvi.io%2Fblog%2Ffalsehoods-programmers-believ= e-about-time-zones%2F%3Futm_source=3Dtldrnewsletter/1/0100018e41b209fb-cd11= af79-9320-4d46-8e6c-11816e5f8ed0-000000/Tv9xFfu7-bq5rla4w2hUsFWmdq1GYt_bCec= -NQjhbaQ=3D344">
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    </span>



    <span style=3D"font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, V= erdana, sans-serif;">
    Building a time zone conversion layer o=
    n top of a datetime library sounds like an easy task, but it isn't. This ar= ticle lists 21 misconceptions about time zones the author had before attemp= ting to write a time zone conversion app as well as extra misconceptions fr=
    om readers. These misconceptions include thinking that there are more count= ries in the world than time zones, that every time zone has exactly one agr= eed-upon name, or that time zones are always offset from UTC by an integer = number of hours.
    </span>
    </span>
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    <table align=3D"center" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" wi= dth=3D"100%"><tbody><tr><td class=3D"container" style=3D"padding: 15px 15px=

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    <span>
    <a href=3D"https://tracking.tldrnewsletter.= com/CL0/https:%2F%2Falexandrehtrb.github.io%2Fposts%2F2024%2F03%2Fhttp2-and= -http3-explained%2F%3Futm_source=3Dtldrnewsletter/1/0100018e41b209fb-cd11af= 79-9320-4d46-8e6c-11816e5f8ed0-000000/PAtc9L2TRdaNB6kzU-tnCZ6lofo657XI_5ZNa= BlNuFU=3D344">
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    (25 minute read)</strong>
    </span>



    <span style=3D"font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, V= erdana, sans-serif;">
    The first HTTP draft had only one metho=
    d, GET - there were no headers or status codes, and the only data format av= ailable was HTML. The protocol has evolved significantly since then. HTTP/3=
    is designed for unstable connections, resulting in performance tradeoffs. = HTTP/2 offers better performance on reliable and stable connections than HT= TP/3. Servers can accept both HTTP/2 and HTTP/3 connections so clients can = make the decision of which version to use.
    </span>
    </span>
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    </td></tr></tbody></table>

    </td></tr></tbody></table>



    <table align=3D"center" bgcolor=3D"" border=3D"0" cellpadding=3D"0" cellspa= cing=3D"0" width=3D"100%"><tbody><tr><td class=3D"container" style=3D"paddi= ng-top: 0px; padding-bottom: 0px;">
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    <div style=3D"text-align: center;"><span style=3D"font-size: 36px;">=F0=9F= =8E=81</span></div></div>
    </td></tr></tbody></table>

    <table align=3D"center" bgcolor=3D"" border=3D"0" cellpadding=3D"0" cellspa= cing=3D"0" width=3D"100%"><tbody><tr><td class=3D"container" style=3D"paddi= ng-top: 0px; padding-bottom: 0px;">
    <div class=3D"text-block">
    <div style=3D"text-align: center;"><strong><h3>Miscellaneous</h3></strong><= /div>
    </div>
    </td></tr></tbody></table>

    <table bgcolor=3D"" style=3D"table-layout: fixed; width: 100%;" width=3D"10= 0%"><tbody><tr><td style=3D"padding:0;border-collapse:collapse;border-spaci= ng:0;margin:0;" valign=3D"top">

    <table align=3D"center" border=3D"0" cellpadding=3D"0" cellspacing=3D"0" wi= dth=3D"100%"><tbody><tr><td class=3D"container" style=3D"padding: 15px 15px=

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    --HD8p8Yrp--


    ---
    ￭ Synchronet ￭ Vertrauen ￭ Home of Synchronet ￭ [vert/cvs/bbs].synchro.net
  • From Digital Man@VERT to TLDR on Fri Mar 15 10:57:23 2024
    Re: SpaceX Starship reaches orbit 🚀, DNA foundational models 🧬, curse of senior devs 👨‍💻
    By: TLDR to tldr@synchro.net on Fri Mar 15 2024 10:39 am

    FALSEHOODS PROGRAMMERS BELIEVE ABOUT TIME ZONES (10 MINUTE READ) [11]

    I discovered all this back in 1992/93 when designing the Synchronet Message Base (SMB) format. Time zones across the world, as I like to say to my kids, are "so cray".
    --
    digital man (rob)

    Synchronet "Real Fact" #91:
    Captured chat with Wayne Bell: http://wiki.synchro.net/history:waynebell_chat Norco, CA WX: 56.6°F, 39.0% humidity, 13 mph NNE wind, 0.00 inches rain/24hrs ---
    ￭ Synchronet ￭ Vertrauen ￭ Home of Synchronet ￭ [vert/cvs/bbs].synchro.net